A mecha anime telling the story of a man who fought against his destiny and succeeded. It is one of my favorite anime, thus the first I talk about. If you haven't seen this already you should. Sure, it's mecha, but it isn't too technical to be disliked by people who don't like mecha (In fact, the only explanation about the robots is that they run on your spirit). Just consider this to be rated M for Manly.
The first episodes can be deceiving; just a show about badass robot fights and fun, where you know the good guys will win by the end of the day (which doesn't make it any bad, though).
However, events that follow make the characters grow. I really enjoyed the characterization of this story, particularly in the MC - Simon. He goes from being a small kid under Kamina's wings, to a grown man capable of facing his destiny. Simon walking away in the end left me a weird bittersweet sensation you can understand if you have watched it too.
After I finished watching I was left with the feeling that I could do anything! Well, I'm exaggerating, but it sure leaves you with the desire to fight the powah.